A Urea Cycle Disorder (UCD) is a genetic disorder that results in a deficiency of some major enzymes in the urea cycle. These enzymes are responsible for removing ammonia from the bloodstream. The urea cycle involves a series of biochemical steps in which nitrogen, a waste product of protein metabolism, is changed to a compound called urea and removed from the blood. Normally, the urea is removed from the body through the urine. In urea cycle disorders, nitrogen builds up in the blood in the form of ammonia, a highly toxic substance, resulting in hyperammonemia (elevated blood ammonia). Ammonia then reaches the brain through the blood, where it can cause irreversible brain damage, coma, and/or death. The onset and severity of urea cycle disorders is highly variable. The severity correlates with the amount of urea cycle enzyme function.
DelveInsight’s “Urea Cycle Disorders Market Report 2030” report delivers an in-depth understanding of the Urea Cycle Disorders, historical and forecasted epidemiology as well as the Urea Cycle Disorders market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
A few of the enzymes which are involved in the Urea Cycle Disorder, collectively known as inborn errors of urea synthesis, or urea cycle enzyme defects; each is referred to by the initials of the missing enzyme: CPS1 (Carbamoyl Phosphate Synthetase), NAGS (N-Acetylglutamate Synthetase), OTC Deficiency (Ornithine Transcarbamylase), AS (Argininosuccinic Acid Synthetase (Citrullinemia)), ASL (Argininosuccinate Lyase (Argininosuccinic Aciduria)), and AG (Arginase).
In children with severe UCD, the symptoms will develop within the first 24 hours of life. Symptoms in children with mild or moderate UCD, who do not show symptoms until early childhood, may include: Vomiting, nausea, Mental confusion or hyperactive behaviour, Tired often and/or hard to awaken, Coma, etc.
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Treatment is a lifelong process that doesn’t cure the condition, but it can effectively manage the symptoms. The child’s treatment probably will involve:
•Low protein, high-calorie diet
•Medications
•Amino acid supplements
•Liver transplantation
Geography Covered
Study Period: 2017-2030
Urea Cycle Disorders Disease Overview
The DelveInsight Urea Cycle Disorders market report gives a thorough understanding of the Urea Cycle Disorders by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis and treatment.
Urea Cycle Disorders Epidemiology Key Findings:
“The estimated incidence of urea cycle disorders at 1 in 35,000 live births in the US or about 113 new patients per year.”
Key pharma players:
1. Ultragenyx Pharmaceutical
2. Acer Therapeutics
3. Aeglea BioTherapeutics
4. Promethera Biosciences
5. Kaleido Biosciences
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Urea Cycle Disorders Market Outlook
The Urea Cycle Disorders market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Urea Cycle Disorders market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand for better technology.
Recent advances in the treatment of inborn errors of urea synthesis have significantly decreased mortality. The treatment of urea cycle disorders consists of dietary management to limit ammonia production, in conjunction with medications and/or supplements that provide alternative pathways for the removal of ammonia from the bloodstream. The aim is to correct biochemical abnormalities and ensure adequate nutritional intake. Treatment involves compounds that increase the removal of nitrogen waste. These compounds convert nitrogen into products other than urea, which are then excreted; hence, the load on the urea cycle is reduced. The first compounds to be used were sodium benzoate and arginine. Later, phenylacetate was used, which has now been replaced by phenylbutyrate.
Hemodialysis is very effective at reducing plasma ammonia and should immediately be initiated if elevated hyperammonemia is observed. Ammonia scavenger medications such as Ammonul IV are also useful. Ammonul IV acts by removing glycine and glutamate from plasma thereby their reducing contribution to ammonia formation.
According to DelveInsight, the Urea Cycle Disorders market in 7MM is expected to change in the study period 2017-2030.
Scope of the Report
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Table of contents1 Key Insight2 Executive Summary of Urea Cycle Disorders3 Urea Cycle Disorders Market Overview at a Glance4 Disease Background and Overview: Urea Cycle Disorders5 Case Reports6 Urea Cycle Disorders Epidemiology and Patient Population7 United States Epidemiology8 EU5 Epidemiology9 Japan Epidemiology10 Current Urea Cycle Disorders Treatment and Medical Practices11 Unmet needs12 Urea Cycle Disorders Marketed Drugs13 Urea Cycle Disorders Emerging Drugs14 Urea Cycle Disorders 7MM Market Analysis15 United States16 EU-5 countries: Market Outlook17 Japan Market Outlook18 Urea Cycle Disorders Market Drivers19 Urea Cycle Disorders Market Barriers20 SWOT Analysis21 Reimbursement and market access22 Appendix23 DelveInsight Capabilities24 Disclaimer25 About DelveInsight
About DelveInsight
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